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Progreso de la infección viral en mellizos hijos de madre infectada por el virus de la inmunodeficiencia humana / Progress of viral infection in twins borned from a human immunodeficiency virus infected mother
Rev. méd. Chile ; 123(10): 1189-98, oct. 1995. tab, graf
Artículo en Español | LILACS | ID: lil-164892
ABSTRACT
We studied the evolution of HIV-1 infection and immune response during six years in 2 twins born from an infected mother. The children had a continous progression of the infection, proved by CD4+ cell counts, serum anti-HIV antibodies, cultivable virus and proviral load. Now, both children are on antiviral treatment. The analysis of serum antibodies showed a different immune response in both children. One of them, developed higher levels of antibodies directed against viral proteins and synthetic peptides derived from their aminoacid sequence. In this child, the amount of cultivable virus increased less than in his twin. Nucleotide sequencing of a part of viral genoma, showed that the virus belonged to the B subtype, prevalent in America and Europe. The observed differences in viral sequences suggest a different selective pressure in both twins. This phenomenon could be related to the observed differences in immune response
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Índice: LILACS (Américas) Asunto principal: Infecciones por VIH / VIH Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Humanos / Masculino Idioma: Español Revista: Rev. méd. Chile Asunto de la revista: Medicina Año: 1995 Tipo del documento: Artículo / Documento de proyecto

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Índice: LILACS (Américas) Asunto principal: Infecciones por VIH / VIH Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Humanos / Masculino Idioma: Español Revista: Rev. méd. Chile Asunto de la revista: Medicina Año: 1995 Tipo del documento: Artículo / Documento de proyecto