Ultrastructure of voluntary muscle in childhood malnutrition
West Indian med. j
; 44(4): 133-9, Dec. 1995.
Article
en En
| LILACS
| ID: lil-165465
Biblioteca responsable:
JM3.1
ABSTRACT
This paper is part of a study on the electron microscopy of protein-energy malnutrition, using a rapid autopsy protocol. Samples of voluntary muscle, obtained from eight children dying of severe oedematous malnutrition, were fised in glutaraldehyde within 75 minutes of death. Atrophy of myofibres, increased prominence of satellite cells, and segmental necrobiosis were seen by light microscopy. Electron microscopy showed variable depletion of myofibrils. In the most severe case, there was focal absence of myofibrils, also disorganized Z lines, and absent M bands. Residual atrophic myofibrils measured less than 0.1 µm in width. Other specimens showed sarcomere disorganization, mitochondrial swelling, glycogen depletion, sarcoplasmic oedema, and focal contractions of sarcomeres. Though non-specific, rigor may phosphates. These conditions may exist in severe malnutrition, complicated by terminal infection and metabolic disturbances
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Índice:
LILACS
Asunto principal:
Desnutrición Proteico-Calórica
/
Músculo Esquelético
Tipo de estudio:
Etiology_studies
Límite:
Female
/
Humans
/
Infant
Idioma:
En
Revista:
West Indian med. j
Asunto de la revista:
MEDICINA
Año:
1995
Tipo del documento:
Article