Infecções fúngicas em 100 pacientes submetidos a transplante cardíaco / Fungal Infections in 100 Patients Submitted to Heart Transplantation

RESUMO

Objetivo - analisar as ocorrências, agentes etiológicos, aspectos clínicos, topografias e números de óbtios referentes às infecçöes fúngicas diagnósticas em grupo de pacientes submetidos a transplante cardíaco (TX). Métodos - foram considerados 100 pacientes, observados consecutivamente, após TX. O período de seguimento variou de 3 a 90 (média 25,38 +/- 25,97) meses. O reconhecimento das infecçöes fúngicas levou em conta os critérios os estabelecidos pelos Centers for Disease Control. Resultados -ouve reconhecimentos de 47 infecçöes, com 3 óbitos atribuíveis diretamente a elas, Acremonium sp, Aspergillus sp, Candida albicans, C.tropicalis, Histoplasma capsulatum e Pneumocystis carinii constituíram os fungos responsáveis. Candidíase da cavidade oral devida à candida albicans representou o acometimento mais comumente comprovado. Conclusäo - as infecçöes fúngicas no grupo avaliado foram responsáveis por 3 óbitos e devem suscitar proprostas profiláticas e terapêuticas

ABSTRACT

Purpose - To evaluate prevalence, causes, clinicalaspects, topography and deaths due to fungal infections diagnosed in a series of patients submitted to heart transplantation. Methods -100 consecutive patients submitted to heart transplantation were studied Follow-up was three to 90 (mean 25.38±25.97) months. Fungal infections were diagnosed by the Centers for Disease Control criteria. Results - Forty seven fungal infections were found, with three deaths caused mainly by fungal infection. The most common infection in this series was oral infection by Candida albicans, Acremonium sp, Aspergillus sp, Candida tropicalis, Histoplasma capsulatum and Pneumocystis carinii were also responsible for infections in this patient population. Conclusion - Fungal infections caused three deaths in this series, and were responsiblefor increased morbidity. The authors suggest prophylactic and therapeutic recommencations