Streptozotocin alters pancreatic beta-cell responsiveness to glucose within six hours of injection into rats
West Indian med. j
; 45(2): 60-2, Jun. 1996.
Article
en En
| LILACS
| ID: lil-169728
Biblioteca responsable:
JM3.1
ABSTRACT
A 24-hour glycaemic profile following streptozotocin (80 mg/kg. ip) injection was investigated in fasted rats. The most prominent changes in blood glucose were hyperglycaemia associated with low levels of plasma insulin after two hours followed by hypoglycaemia associated with high levels of plasma insulin after six hours; subsequently hyperglycaemia progressively developed and this was associated with decreasing levels of plasma insulin. Further probing revealed that at two hours after streptozotocin injection, the pancreatic ß-cells could not respond to an oral glucose load while, at six hours after, there was an apparent return of ß-cell responsiveness, but subsequently ß-cell responsiveness was progressively lost and histological examination revealed cellular damage. From these results, it is concluded that within six hours of injection, stretozotocin initiates pancreatic ß-cell damage which leads to the development of diabetes mellitus.
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Índice:
LILACS
Asunto principal:
Glucemia
/
Islotes Pancreáticos
/
Estreptozocina
Límite:
Animals
Idioma:
En
Revista:
West Indian med. j
Asunto de la revista:
MEDICINA
Año:
1996
Tipo del documento:
Article