Cellular receptors, acceptors and clinical implications

RESUMO

Evidence of the existence of a special decodifier on the effector cells, with which inductor substances must interact in order to trigger their characteristic responses, has been found since the beginning of the century. These cytoplasmic sites are able to recognize, accept and receive the massage transmitted by the inductor substance, giving rise to a specific cell response. Thus, the inductor-receptor binding complex interaction at the cellular level may alter permeability to ions as happens with neurotransmitters, or can trigger ponocytosis in the case of apolipoproteins. Cellular receptors have been involved in the mechanism of action of several drugs and its dysfunction explains the physiopathology of a number of diseases. This may involve diminished clathrin protein synthesis triggering a defect in affinity, such as seen in malnutrition. It is also applicable in genetic distrurbances, which are capable of precluding receptor development as in cases of familiar hypercholesterolemia