The incidence of lethal graft-versus-host disease in rat limb allotransplantations

Ferreira, L. M; Borsanyi, J. P; Benhaim, P; Anthony, J. P; Mathes, S. J; Andrews, J. M; Laredo Filho, J

Ferreira, L. M; Borsanyi, J. P; Benhaim, P; Anthony, J. P; Mathes, S. J; Andrews, J. M; Laredo Filho, J.

Rev. Hosp. Säo Paulo Esc. Paul. Med ; 6(1/2): 7-10, Jan.-Jun. 1995. ilus

Artículo en Inglés | LILACS | ID: lil-179684

ABSTRACT

ABSTRACT

To study graft-versus-host disease (GVHD) in rat hindlimb allotransplantation, a model similar to intestinal transplantation was used. ACI and Lewis rats were crossed to produce F(1) generation rats (ACI-Lewis). These underwent limb transplantation receiving a donor limb from a Lewis rat. The animals were examined daily and skin biopsies were performed. Results showed that all limbs were viable at 34 weeks and no rats demonstrated any clinical evidence of GVHD and biopsies were grade 0.

Asunto(s)

Animales; Ratas; Enfermedad Injerto contra Huésped/epidemiología; Extremidades/trasplante; Incidencia; Ratas Endogámicas; Ratas Endogámicas Lew; Piel/patología; Trasplante Homólogo

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Índice: LILACS (Américas) Asunto principal: Extremidades / Enfermedad Injerto contra Huésped Tipo de estudio: Estudio de incidencia / Estudio pronóstico / Factores de riesgo Límite: Animales Idioma: Inglés Revista: Rev. Hosp. Säo Paulo Esc. Paul. Med Asunto de la revista: Medicina Año: 1995 Tipo del documento: Artículo

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