Rat limb allotransplantation: efficacy of subtherapeutic dose combination immunotherapy with cyclosporine (CsA) and RS-61443
Rev. Hosp. Säo Paulo Esc. Paul. Med
;
6(1/2): 15-9, Jan.-Jun. 1995. ilus
Artículo
en Inglés
| LILACS
| ID: lil-179686
RESUMO
The synergic effect of subtherapeutic doses of cyclosporine and RS-61443 was demonstrated in a vascularized rat hindlimb allotransplantation across a strong histocompatibility barrier (Brown-Norway as donors and Fischer 344 as recipients). Low doses of agents in combination minimized the toxicity while increasing the therapeutic efficacy. All animals showed weight loss during the first 15 days posttransplantation and they regained protective sensation within 45 postoperative days. Only 15.38 per cent of the animals presented complications thrombosis, enteritis, autophagia and disorders of unknown etiology.
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Índice:
LILACS (Américas)
Asunto principal:
Ciclosporina
/
Quimioterapia Combinada
/
Extremidades
/
Rechazo de Injerto
/
Inmunosupresores
/
Ácido Micofenólico
Tipo de estudio:
Estudio de etiología
Límite:
Animales
Idioma:
Inglés
Revista:
Rev. Hosp. Säo Paulo Esc. Paul. Med
Asunto de la revista:
Medicina
Año:
1995
Tipo del documento:
Artículo
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