Immunodiffusion exo-antigen and elisa serologies evaluation in twenty paracoccidioidomycosis (PBM) patients

ABSTRACT

Serological evaluation was performed in 20 active chronic pulmonary PBM patients males with age ranging from 20 to 60 years. Farmaer workers, heavy smokers, alcoholic and long duration of disease (5 to 25 years) were observed in these patients. Tegumentary lesions were found in 18 of them, cough in 18, dyspnea in 17, COPD in 6 and hoarseness in 2. The initial mild bilateral interstitial fibromodular infiltrate (15 por cento); moderate (40 por cento) and severe (45 por cento) canged to mild (15 por cento), moderate (20 por cento) and severe (65 por cento) during the follow-up of the lung X-ray study. Immunodiffusion (ID) exo-antigen in 3 patients and positive Elisa polyclonal (polyglobulins) 1/800 reactions in 2 were related to mild or without lesions, mean while ID > 1/4 and Elisa (1/1600 to 1/52000) seric levels were associated with maintenance or worsening of the pulmonary lesion types