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A comparative study of the organic acid content of the hemolymph of Schistosoma mansoni-resistant and susceptible strains of Biomphalaria glabrata
Mem. Inst. Oswaldo Cruz ; 92(3): 421-5, May-Jun. 1997. graf
Artículo en Inglés | LILACS | ID: lil-189318
ABSTRACT
The freshwater snail Biomphalaria glabrata is an intermediate host of the trematode Schistosoma mansoni. However, some strains of B. glabrata are resistant to successful infection by S. mansoni larvae. The present work examines the profile of organic acids present in S. mansoni-resistant and susceptible strains of B. glabrata, in order to determine whether the type of organic acid present is related to susceptibility. The organic acids were extracted from the hemolymph of two susceptible B. glabrata strains (PR, Puerto Rico and Ba, Jacobina-Bahia from Brazil), and from the resistant strains 13-16-R1 and 10R2, using solid phase extraction procedures followed by high performance liquid chromatography. The organic acids obtained were analyzed and identified by comparison with known standards. Pyruvate, lactate, succinate, malate, fumarate, acetate, propionate, ß-hydroxybutyrate and acetoacetate were detected in all hemolymph samples. Under standard conditions, the concentration of each of these substances varied among the strains tested and appeared to be specific for each strain. An interesting variation was the low concentration of pyruvate in the hemolymph of PR-snails. Only the concentration of fumarate was consistently different (pó0.05) between resistant and susceptible strains.
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Schistosoma mansoni / Biomphalaria / Hemolinfa Límite: Animales País/Región como asunto: America del Sur / Brasil Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 1997 Tipo del documento: Artículo

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Schistosoma mansoni / Biomphalaria / Hemolinfa Límite: Animales País/Región como asunto: America del Sur / Brasil Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 1997 Tipo del documento: Artículo