Actividad de metaloproteinasas de arterias y venas y su regulación mediante doxiciclina / Metalloproteinase activity of arteries and veins and it regulation through doxycicline
Rev. méd. Chile
;
125(1): 7-15, ene. 1997. ilus
Artículo
en Español
| LILACS
| ID: lil-194517
ABSTRACT
Segments of internal mammary arteries and saphenous veins and cultured smooth muscle cells were incubated with and without doxycicline. Metalloproteinases activity was assessed by zymography and Western Blot. Activity of Metalloproteinase-9 in saphenous veins was 217 percent less than in internal mammary arteries. In these vessels doxycicline decreased metalloproteinase-9 activity by 207 percent and metalloproteinase-1 expression. In cultured smooth muscle cells, the median inhibitory concentration of doxycicline for metalloproteinase-2 was 138 uM (r2=0.82). Internal mammary arteries and saphenous veins have different metalloproteinase activities, that are inhibited by doxycicline
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Índice:
LILACS (Américas)
Asunto principal:
Técnicas In Vitro
/
Doxiciclina
/
Metaloproteasas
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
1997
Tipo del documento:
Artículo
/
Documento de proyecto
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