Expresión inmunohistoquímica de la oncoproteína p53 en adenomas y adenocarcinomas del intestino grueso / Immunohistochemical expression of p53 oncoprotein in large bowel adenomas ans carcinomas
Rev. méd. Chile
; 125(5): 523-9, mayo 1997. tab, ilus
Article
en Es
| LILACS
| ID: lil-196297
Biblioteca responsable:
CL1.1
RESUMO
Material and methods:
A random sample of 28 large bowel adenomas and 44 carcinomas was studied. Determination of p53 protein was made with an immunohistochemical method using monoclonal antibodies. Patients were followed for a mean of 36 months (range 1 to 100 months).Results:
p53 immunostaining was obtained in one adenoma (3.5 percent) and in 18 carcinomas (41 percent, p = 0.01). There were no differences in survival during follow up, between cancer patients that expressed or did not express p53 protein.Conclusions:
About half of colorectal tumors have immunohistochemical expression of p53 protein, as published abroad. We did not find a prognostic value for this protein in our sample
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Índice:
LILACS
Asunto principal:
Inmunohistoquímica
/
Neoplasias Colorrectales
/
Proteína p53 Supresora de Tumor
/
Proteínas Oncogénicas
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
Es
Revista:
Rev. méd. Chile
Asunto de la revista:
MEDICINA
Año:
1997
Tipo del documento:
Article
/
Project document