Involvement of hippocampal AMPA glutamate receptor changes and the cAMP/protein kinase A/CREB-P signaling pathway in memory consolidation of an avoidance task in rats
Braz. j. med. biol. res
;
30(8): 961-5, Aug. 1997. graf
Artículo
en Inglés
| LILACS
| ID: lil-197252
ABSTRACT
Training in step-down inhibitory avoidance (0.3-mA footshock) is followed by biochemical changes in rat hippocampus that strongly suggest an involvement of quantitative changes in glutamate AMPA receptors, followed by changes in the dopamine D1 receptor/cAMP/protein kinase A (PKA)/CREB-P signalling pathway in memory consolidation. AMPA binding to its receptor and levels of the AMPA receptor-specific subunit GluR1 increase in the hippocampus within the first 3 h after training (20-70 per cent). Binding of the specific D1 receptor ligand, SCH23390, and cAMP levels increase within 3 or 6 h after training (30-100 per cent). PKA activity and CREB-P levels show two peaks a 35-40 per cent increase 0 h after training, and a second increase 3-6 h later (35-60 per cent). The results correlate with pharmacological findings showing an early post-training involvement of AMPA receptors, and a late involvement of the D1/cAMP/PKA/CREB-P pathway in memory consolidation of this task.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Reacción de Prevención
/
Transducción de Señal
/
Proteína de Unión a Elemento de Respuesta al AMP Cíclico
/
Receptores AMPA
/
Proteínas Quinasas Dependientes de AMP Cíclico
/
Hipocampo
/
Memoria
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1997
Tipo del documento:
Artículo
/
Congreso y conferencia
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