Bioequivalence study for diazepam commercial tablets in psychiatric patients
Arch. med. res
;
25(1): 23-7, 1994. tab, ilus
Artículo
en Inglés
| LILACS
| ID: lil-198799
RESUMO
The bioequivalence of three different commercial diazepan tablets (5mg) using the innovator product (Valium, Roche) as a reference was evaluated in eight psychiatric patients, following a multiple-dose regimen (5 mg t.i.d.). Each patient receive the four treatments sequentially according to a Latin square design, with balance for first residual effect. Blood samples were taken once the steady state of the drug had been reached, and the plasma levels were determined using a HPLC method. No statistical differences were found in diazepam steady-state levels after the adminsitration of the four formulations, indicating that they could be aconsidered equivalent
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Índice:
LILACS (Américas)
Asunto principal:
Volumen Plasmático
/
Psiquiatría
/
Equivalencia Terapéutica
/
Diazepam
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Arch. med. res
Asunto de la revista:
Medicina
Año:
1994
Tipo del documento:
Artículo
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