A putative antiidiotype autoantibody regulates the antibromelain treated mouse red blood cell autoantibody secretion
Ciênc. cult. (Säo Paulo)
;
46(5/6): 399-403, Sept.-Dec. 1994. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-199870
ABSTRACT
Murine normal lymphoid tissues contain relatively high numbers of anti-BrMRBC RFC and PFC. In the bone marrow, these frequencies are inversely correlated probably due to different activation states of these anti-BrMRBC B cells. The sera from syngeneic, but not allogeneic, mice are able to inhibit the formation of these anti-BrMRBC plaques. This inhibition is enhanced when sera of LPS treated mice is employed. The inhibitory factor can be displaced from normal spleen cells by 10(-5) M phosphorylcholine (PC) hapten reversing the PFC inhibition. The dialyzed and concentrated supernatant from PC incubated splenocytes completely abolishes anti-BrMRBC PFC. Preliminary data suggest that the molecular weight of the inhibitory factor is higher than 600 KDa. We postulate an antiidiotype autoantibody nature for this inhibitory factor.
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Índice:
LILACS (Américas)
Asunto principal:
Autoanticuerpos
/
Anticuerpos Antiidiotipos
/
Eritrocitos
Límite:
Animales
Idioma:
Inglés
Revista:
Ciênc. cult. (Säo Paulo)
Asunto de la revista:
Ciencia
Año:
1994
Tipo del documento:
Artículo
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