Pharmacokinetics of oral ranitidine in Mexicans
Arch. med. res
;
27(3): 349-52, 1996. tab, ilus
Artículo
en Inglés
| LILACS
| ID: lil-200335
RESUMO
The pharmacokinetics of oral ranitidine were studied in 24 Mexican male healthy volunteers. Subjects received a tablet containing 150 mg of ranitidine (Azantac TM, Glaxo de Mexico, Mexico, City) after an overnight fast and blood samples were drawn at several times for a period of 24 h. Ranitidine concentration in plasma was measured by high performance liquid chromatography and pharmacokinetic parameters were determined by non-compartmental analysis. Ranitide plasma concentration increased with time, reaching a maximum of (mean ñ SEM) 484 ñ 34 ng/ml in 2.7 ñ 0.2 h. Plasma levels then decayed with a terminal half-life of 4.8 ñ 0.3 h. The area under the plasma concentration against time curve was 2440 ñ 126 ngh/ml. Oral ranitidine pharmacokinetic parameters in mexicans appeared to be similar to those previously reported for caucasians
Buscar en Google
Índice:
LILACS (Américas)
Asunto principal:
Plasma
/
Ranitidina
/
Farmacocinética
/
Cromatografía
/
Nizatidina
/
Cloruro de Metileno
Límite:
Adulto
/
Humanos
/
Masculino
País/Región como asunto:
México
Idioma:
Inglés
Revista:
Arch. med. res
Asunto de la revista:
Medicina
Año:
1996
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS