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Detection of cytotoxic activity on Vero cells in clinical isolates of Serratia marcescens
Braz. j. med. biol. res ; 30(11): 1291-8, Nov. 1997. ilus, tab, graf
Artículo en Inglés | LILACS | ID: lil-201672
ABSTRACT
Cytotoxin production was studied in 60 Serratia marcescens strains isolated from hospitalized patients. Association of cytotoxic activity with serotype, source of isolation and presence of plasmids was also evaluated. Thirteen of the 60 S. marcescens strains produced a cytotoxic effect of Vero cells. These strains were isolated from distinct clinical sources and classified into seven different serotypes (O1H7; O4NM; O10NT; O19NM; O6,14H4; O6,14NM and O6,14H1). No relationship was observed between cytotoxic activity and clinical source or serotypes of the strains. Plasmids from five cytotoxin-producing S. marcescens strains were transferred to E. Coli K12/711. The transconjugants did not exhibit cytotoxicity, indicating that the cytotoxic effect is not plasmid-mediated among these strains. Although a cytotoxic activity was demonstrated in filtrates of some S. marcescens strains, further studies should be performed to assess the role of this toxin in pathogenesis.
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Serratia marcescens / Técnicas In Vitro / Citotoxinas Tipo de estudio: Estudio diagnóstico Límite: Humanos Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 1997 Tipo del documento: Artículo

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Serratia marcescens / Técnicas In Vitro / Citotoxinas Tipo de estudio: Estudio diagnóstico Límite: Humanos Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 1997 Tipo del documento: Artículo