Response to heterologous leishmanins in cutaneous leishmaniasis in Nigeria - discovery of a new focus
Mem. Inst. Oswaldo Cruz
;
93(1): 23-7, Jan.-Feb. 1998. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-201988
RESUMO
A pilot study was undertaken to preliminary illustrate the leishmanin skin test (LST) positivity to distinct antigen preparations (derived from promastigote of either Leishmania major or L. amazonensis, or pooled L. mexicana, L. amazonensis and L. guyanensis) in cutaneous leishmaniasis (CL) patients and healthy subjects living in two endemic foci in Nigeria. The study was designed to provide insights into whether cross-species leishmanin, such as that prepared from New World Leishmania could be useful to detect cases of Old World leishmanial infection and to compare the results with LST using L. major-derived leishmanin. The overall LST positivity in individuals from Keana tested with the cross-major-derived leishmanin was 28.7 per cent (27/94), while the positivity rate in the subjects from Kanana tested with the same leishmanin was 54.5 per cent (6/11). Lower positivity values were obtained when L. major (12.5 per cent; 11/88) or L. amazonensis (15.8 per cent; 9/57) was tested as antigen in grossly comparable populations. Moreover, the pooled leishmanin identified most of the subjects (13/14; 92.9 per cent) with active or healed CL, and the maximum reaction sizes were found among positive subjects in this group. No healthy controls (10 total) showed specific DTH response. The LST was useful for assessing the prevalence of subclinical infection and for measuring CL transmission over time. We report for the first time the occurrence of CL in Kanana village of Langtang South local government area of Plateau State.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Antígenos Heterófilos
/
Leishmaniasis Cutánea
Tipo de estudio:
Factores de riesgo
Límite:
Humanos
País/Región como asunto:
Africa
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
1998
Tipo del documento:
Artículo
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