A new murine model of persistent lung eosinophilic inflammation
Mem. Inst. Oswaldo Cruz
;
92(supl.2): 215-8, Dec. 1997. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-202036
RESUMO
We summarize here the main characteristics of a novel model of pulmonary hypersensitivity. Mice were immunized with a subcutaneous implant of a fragment of heat solidified chicken egg white and 14 days later challenged with ovalbumin given either by aerosol or by intratracheal instillation. This procedure induces a persistent eosinophilic lung inflammation, a marked bone marrow eosinophilia, and Th2-type isotypic profile with histopathological findings that resemble human asthma. Further, this model is simple to perform, reproducible in different strains of mice, does not require adjuvants nor multiple boosters. Based on these characteristics we propose it as a suitable murine model of allergic eosinophilic lung inflammation.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Eosinofilia Pulmonar
/
Hipersensibilidad Respiratoria
/
Asma
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
1997
Tipo del documento:
Artículo
/
Congreso y conferencia
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