Inyección intraesfinteriana de toxina botulínica en pacientes con acalasia esofágica / Intrasphincteric injection of botulinum toxin in patients with achalasia
Rev. méd. Chile
;
125(8): 899-904, ago. 1997. ilus, tab
Artículo
en Español
| LILACS
| ID: lil-207127
ABSTRACT
Eight patients received 80 units of BoTx. Assessment of response was based on changes in the symptom scores (0-9) and esophageal manometric studies. Results:
Six out of 8 patients (75 percent) had sustained clinical improvement after therapy. This effect was maintained for a mean time of 17.8 months. The symptom score decreased from a mean of 6.7 to 0.5 (p < 0.01) and after treatment, LES pressure decreased from 63 to 25.5 mm Hg (p = 0.07).l There were no serious adverse effects. Five of the six responders have relapsed. Two of these patients received a second BoTx infection with satisfactory results, two went to surgery and one refused other type of therapy and died of pneumonia.Conclusions:
Intrasphincteric BoTx injection is a simple, safe and effective method of treatment in patients with achalasia, with a duration of response averaging 1.5 years. Its use may be suggested in some patients with high surgical risk and those who refuse a more invastive therapy. It is also useful in malnourished patients to attain an adequate nutritional status before surgery
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Índice:
LILACS (Américas)
Asunto principal:
Toxinas Botulínicas
/
Acalasia del Esófago
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
1997
Tipo del documento:
Artículo
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