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Somatotrophic and corticotrophic function outcome after trasesphenoidal surgery in patients with sellar tumors and pre-operative endocrine deficits
Arq. neuropsiquiatr ; 55(3A): 387-92, set. 1997. tab, graf
Artículo en Inglés | LILACS | ID: lil-209524
ABSTRACT
Sixteen patients with sellar tumors that were treated surgically and who had pre-operative somatotrophic and corticotrophic function deficits were submitted to pre- and post-operative insulin tolerance tests (ITTs). Seven patients had non-functioning adenomas, 5 had prolactinomas, 3 had craniopharyngioma and 1 had cordoma of the clivus. All patients had macro-tumors and none received radiotherapy within the studied period. Seven patients had GH, 4 had cortisol and 5 had both GH/cortisol function pre-operative deficit. Five patients with isolated GH, 4 with isolated cortisol and 3 with both GH/cortisol deficiencies showed a postoperative functional recovery. New cortisol secretion deficits were observed in 2 patients postoperatively and both required long-term steroid replacement. These data suggest that preoperative endocrine deficits may be reversible after surgical decompression of the sellar region and that new endocrine deficits are rarely seen after surgery. All such patients should be tested postoperatively from an endocrinological point of view to reevaluate the need for replacement therapies.
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Neoplasias Hipofisarias / Sistema Hipotálamo-Hipofisario Límite: Adulto / Femenino / Humanos Idioma: Inglés Revista: Arq. neuropsiquiatr Asunto de la revista: Neurología / Psiquiatria Año: 1997 Tipo del documento: Artículo

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Neoplasias Hipofisarias / Sistema Hipotálamo-Hipofisario Límite: Adulto / Femenino / Humanos Idioma: Inglés Revista: Arq. neuropsiquiatr Asunto de la revista: Neurología / Psiquiatria Año: 1997 Tipo del documento: Artículo