Asociación entre heterocigocidad materna para cinco grupos sanguíneos y éxito reproductivo / Association between maternal heterozygosity for five blood groups and reproductive success
Rev. méd. Chile
;
126(1): 27-31, ene. 1998. ilus
Artículo
en Español
| LILACS
| ID: lil-210406
RESUMO
Background:
In man, blood groups are polymorphic genetic systems. Maternal fetal incompatibility phenomena should lead to an elimination rather than a maintenance of these polymorphisms. Apossible mechanism that could explain the persistence of these polymosphisms in natural populations is a selective reproductive advantage of heterozygous individuals.Aim:
To explore the relationship between maternal heterozygosity for five blood grups and some obstetrical variables related to gestational success. Material andmethods:
Using a case control design, to every mother giving birth to a malformed child a consecutive mother, whose offspring was normal, was assigned as control. All women were typified for ABO, Rh, kidd, MNSs and Duffy blood groups.Results:
Two hundred two women were studiend. There was only one stillbirth, born from a heterozygous mother for all analyzed loci. Mothers that were heterozygous or homozygous for all loci had a higher frequency of malformed children. Women homozygous for all loci had a higher frequency of living offspring than the rest of the sample.Conclusions:
Heterozygous mothers for these genetic systems have a reproductive disadvantage
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Índice:
LILACS (Américas)
Asunto principal:
Reproducción
/
Antígenos de Grupos Sanguíneos
/
Tamización de Portadores Genéticos
Tipo de estudio:
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Recién Nacido
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
1998
Tipo del documento:
Artículo
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