Analogues and prodrugs, permanent useful alternatives to improve the effectiveness of natural anticancer compounds: Enhanced activity of slightly soluble salts of olivacine in L1210 leukemia
Ciênc. cult. (Säo Paulo)
;
49(5/6): 370-7, Sept.-Dec. 1997. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-214099
RESUMO
Several derivatives of well-known natural anticancer drugs have been synthesized and will continue to be, to overcome their delivering problems, or effectiveness. Characteristics such as poor solubility, metabolic inactivation, resistance development, rapid clearance or short half-life, adverse side effects like nausea, alopecia, anorexia are common undesirable limitations to their clinical use. Drug toxicity to less sensitive tumors as those in liver or brain is another aimed goal. Recent efforts to reverse undesirable physicochemical properties of well-established natural anticancer compounds are focused. Improved antitumor action of olivacine in L(1210) leukemia with slightly soluble halides with increased life span as well as "cured" animals was observed.
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Índice:
LILACS (Américas)
Asunto principal:
Leucemia L1210
/
Elipticinas
/
Antineoplásicos Fitogénicos
Tipo de estudio:
Revisiones Sistemáticas Evaluadas
Límite:
Humanos
Idioma:
Inglés
Revista:
Ciênc. cult. (Säo Paulo)
Asunto de la revista:
Ciencia
Año:
1997
Tipo del documento:
Artículo
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