Effects of chronic infusion of nerve growth factor (NGF) in rats with nucleus basalis magnocellularis lesion
La Habana; s.n; 1996. 4 p. tab, graf.
No convencional
en Inglés
| LILACS
| ID: lil-223657
RESUMO
We attempted to evaluate the effects of bilaeral injection of ibotenic acid (IA) into the nucleus basalis magnocelluraris (rbm) of rats as well as the potential recovery mediated by the infusion of nerve growth factor (NGF). The lesion caused and impairment of learning and memory processes. Also, a severe depletion of choline acetyl transferase activity was detected in cortical areas. After the NGF administration, a significant reversion of these functional changes was observed. Thus, IA-lesioned rats might serve as a model for the evaluation of neurotrophic factors actions on basal forebrain damaged neurons
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Índice:
LILACS (Américas)
Asunto principal:
Ratas
/
Sustancia Innominada
/
Cognición
/
Ácido Iboténico
/
Factores de Crecimiento Nervioso
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Año:
1996
Tipo del documento:
No convencional
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