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Tachyphylaxis and sensitization to nicotine-induced tachycardiac and pressor effects after nicotine infusions
Arch. med. res ; 28(2): 189-94, jul. 1997. tab, ilus
Artículo en Inglés | LILACS | ID: lil-225213
RESUMO
This work examined the effects of nicotine on mean arterial pressure and heart rate in non-anesthetized as a single bolus, as infusions lasting 7.5, 15 or 30 min, and as a post-infusion bolus. A nicotine bolus increased pressure and rate. These effects were less marked as the rate of infusion decreased. The infusions affected differentially the effects of a subsequent bolus. Thus, while tachycardia was decreased, the blood pressure rise was increased. An initial transiet bradycardia was observed after bolus administration, but not during infusions; this effect was unchaged after post-infusion boluses. Pharmacological analysis indicated that tachycardia and bradycardia were predominantly due to ganglionic stimulation, while adrenal and sumpathetic nerve catecholamine release played a major role in the pressor response., These results indicate that slow nicotine infusions do not induce tachyphylaxis for all of the cardiovascular effects of a subsequent bolus, and that development of acute tolerance appears to depend on the mechanism of action of the response
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Índice: LILACS (Américas) Asunto principal: Presión Sanguínea / Bradicardia / Esquema de Medicación / Ratas Wistar / Frecuencia Cardíaca / Hipertensión / Inyecciones Intravenosas / Nicotina Límite: Animales Idioma: Inglés Revista: Arch. med. res Asunto de la revista: Medicina Año: 1997 Tipo del documento: Artículo

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Índice: LILACS (Américas) Asunto principal: Presión Sanguínea / Bradicardia / Esquema de Medicación / Ratas Wistar / Frecuencia Cardíaca / Hipertensión / Inyecciones Intravenosas / Nicotina Límite: Animales Idioma: Inglés Revista: Arch. med. res Asunto de la revista: Medicina Año: 1997 Tipo del documento: Artículo