Adult gerbil epidermal cells resistant to terminal differentiation associated with initiation of carcinogenesis
Acta cient. venez
;
48(3): 134-8, 1997. ilus
Artículo
en Inglés
| LILACS
| ID: lil-228495
ABSTRACT
In order to identify the cellular basis of the gerbil skin unresponsiveness to two-stage carcinogenesis, it was studied the effect of an initiating dose of carcinogen on the biological behaviour of gerbil skin. Treatment of adult gerbil epidermal cells either in vivo or in vitro with 3-methylcholanthrene yielded cells which were resistant to terminal differentiation induced by calcium. These results support the concept derived from the mouse model system of skin carcinogenesis in which initiation is associated with an altered program of epidermal differentiation. The results also suggest that relative resistance of gerbil skin to two-stage carcinogenesis is related to promotion stage
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Índice:
LILACS (Américas)
Asunto principal:
Carcinógenos
/
Epidermis
Tipo de estudio:
Factores de riesgo
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cient. venez
Asunto de la revista:
Ciencia
Año:
1997
Tipo del documento:
Artículo
País de afiliación:
Brasil
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