Smooth muscle cell diversity and the extracellular matrix in a rat model of restenosis
P. R. health sci. j
;
15(3): 187-91, Sept. 1996.
Artículo
en Inglés
| LILACS
| ID: lil-228510
ABSTRACT
Clear differences exist in the incidence and severity of atherosclerotic plaques that arise in different segments of the arterial tree. Aortic homograft transplant experiments in dogs showed that the greater incidence of plaque formation in the abdominal versus the thoracic aorta was due to intrinsic differences in the cell populations in these two segments rather than to hemodynamic factors. What is the basis for SMC diversity within a common vessel wall? Recent lineage analysis studies in the avian and mammalian embryo indicate that two distinct SMC lineages contribute to the formation of the major elastic outflow arteries including the aorta. A mixture of unique SMC types of diverse developmental lineages within a common vessel wall raises new questions about the potential for SMC type-specific responses to growth factors and cytokines involved in human atherosclerosis and restenosis
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Índice:
LILACS (Américas)
Asunto principal:
Angioplastia Coronaria con Balón
/
Enfermedad Coronaria
/
Modelos Animales de Enfermedad
/
Matriz Extracelular
/
Músculo Liso Vascular
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
P. R. health sci. j
Asunto de la revista:
Medicina
Año:
1996
Tipo del documento:
Artículo
País de afiliación:
Brasil
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