Central noradrenergic hyperactivity early in life: a hypothesis on the origin of morpho-functional brain disorders induced by malnutrition

ABSTRACT

Many studies have revealed that malnutrition, caused either by insufficient or unbalanced diet, during early stages of growth and development could result in a variety of morpho-functional brain disturbances, whose severity depends on the time of onset, duration and intensity of the nutritional injury. Nevertheless, little is known about the intimate mechanisms by which early malnutrition impairs brain structure and function. This article reviews evidence showing that (i) developmental malnutrition induces central noradrenergic hyperactivity, (ii) noradrenaline exerts a trophic role during brain development, and (iii) pharmacological reduction of central noradrenergic hyperactivity prevents malnutrition-induced functional brain disturbances