Trypanosoma cruzi topoisomerase II: a target enzyme for the chemotherapy of Chagas' disease? Cloning and characterization of its encoding gene
Biol. Res
; 26(1/2): 77-80, 1993.
Article
en En
| LILACS
| ID: lil-228619
Biblioteca responsable:
BR1.1
ABSTRACT
The study of Trypanosoma cruzi type II DNA-topoisomerase should provide new clues for the rational development of new drugs for the chemotherapy of Chagas' disease. This enzyme is very likely involved in the processes leading to T. cruzi replication and differentiation since both processes are blocked by bacterial type II DNA topoisomerase inhibitors. In this article, we review and discuss our recent data related to the cloning, sequencing, and expression of T. cruzi type II topoisomerase
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Índice:
LILACS
Asunto principal:
Trypanosoma cruzi
/
Genes Protozoarios
/
ADN-Topoisomerasas de Tipo II
Límite:
Animals
Idioma:
En
Revista:
Biol. Res
Asunto de la revista:
BIOLOGIA
Año:
1993
Tipo del documento:
Article