A simple experimental model of heat shock response in rats
Acta cir. bras
;
13(4): 217-21, out.-dez. 1998. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-230476
RESUMO
Objective:
To obtain a simple model for the elicitation of the heat shock response in rats.Design:
Laboratory study.Setting:
University research laboratories. Sample Seventy-nine adult male albino rats (weight range 200g to 570g). Procedures Exposure to heat stress by heating animals in a warm bath for 5 min after their rectal temperatures reached 107.60 F (42 degrees Celsius). Liver and lung samples were collected for heat-shock protein 70 (HSP70) detection (Western analysis).Results:
Western analysis was positive for HSP70 in the liver and in the lungs of heated animals. There was a temporal correlation between heating and HSP70 detection it was strongest one day after heating and reduced afterwards. No heated animals died.Conclusion:
These data show that heating rats in a warm (45 degrees Celsius) bath, according to parameters set in this model, elicits efficiently the heat shock response.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Respuesta al Choque Térmico
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
1998
Tipo del documento:
Artículo
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