Risk factors for esteroid diabetes in rheumatic patients
Arch. med. res
;
29(3): 259-62, jul.-sept. 1998. tab
Artículo
en Inglés
| LILACS
| ID: lil-232643
RESUMO
Background. Steroid induced diabetes (SDM) has been known for a long time, but its pathophysiological mechanisms as well as its predisposing factors remain unknown. Method. In order to investigate the different factor related to the development of steroid diabetes (SDM) in patients with rheumatic diseases, we studied 27 patients with SDM, and 27 age-and sex-matched controls who also received therapy with glucocorticoids. In every case, family history of DM, body mass index, associated treatment, steroid dose and treatment duration were studied; fasting serum insulin, "C" peptide, growth hormone and glucagon levels were measured. Results. All of the patients received prednisone. Cumulated prednisone dose was the only factor significantly associated with the development of SDM. patients with SDM had a cumulated ose of 26.6 ñ 28 g (M ñ SD), while the control group received 11.6 ñ 11 g (p<0.02) (odds ratio, 6.35). Serum insulin levels were not significantly different, but insulin/glucose ratio was lower in SDM (0.104 ñ 0.05) than in the control group (0.163 ñ 0.07) (p<0.05). Conclusions. These findings suggest that high cumulated prednisone dose may induce DM regardless of another hereditary or personal predisposing factor
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Índice:
LILACS (Américas)
Asunto principal:
Prednisona
/
Antiinflamatorios no Esteroideos
/
Enfermedades Reumáticas
/
Administración Oral
/
Factores de Riesgo
/
Gliburida
/
Diabetes Mellitus
/
Hipoglucemiantes
/
Insulina
/
Antiinflamatorios
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Arch. med. res
Asunto de la revista:
Medicina
Año:
1998
Tipo del documento:
Artículo
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