Rendimiento del xenodiagnótico y el PCR para evaluar el tratamiento quimioterápico específico de la enfermedad de Chagas en niños / Yielding of skin diagnosis and PCR for the evaluation of specific chemotherapy of Chagas's disease in children
Bol. chil. parasitol
;
53(1-2): 27-9, ene.-jun. 1998. ilus, tab
Artículo
en Español
| LILACS
| ID: lil-233095
ABSTRACT
Amplification by the polymerase chain reaction (PCR) of Trypanosoma cruzi kinetoplastic DNA was used to enhance sentitivity in the detection of the parasite in blood, with the ultimate goal of improving the parasitological diagnosis of Chagas' disease in 0-10 year-old infected children. Twenty eight children were evaluated by using xenodiagnosis (XD) and PCR. Whereas XD detected 75,0 percent of the cases PCR was positive in 96,8 percent. The usefulness of the PCR was further investigated in the 28 children who have received specific treatment with nifurtimox. Negativetion of XD after three and six months post treatment respectively. These observations suggest that PCR is the most sensitive and quick technique available for direct detection of T. cruzi in chagasic children and that it can be a very useful tool for the follow-up of infected subjects after specific chemotherapeutical treatment
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Índice:
LILACS (Américas)
Asunto principal:
Trypanosoma cruzi
/
Reacción en Cadena de la Polimerasa
/
Enfermedad de Chagas
Tipo de estudio:
Estudio diagnóstico
Límite:
Niño
/
Child, preschool
/
Humanos
/
Lactante
/
Recién Nacido
Idioma:
Español
Revista:
Bol. chil. parasitol
Asunto de la revista:
ALIMENTOS
/
Parasitología
Año:
1998
Tipo del documento:
Artículo
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