Antipsychotic profile of alstonine: ethnopharmacology of a traditional Nigerian botanical remedy
An. acad. bras. ciênc
;
71(2): 189-201, jun. 1999. ilus, graf
Artículo
en Inglés
| LILACS
| ID: lil-234513
ABSTRACT
Although recently developed drugs have brought significant improvement, the treatment of psychotic disorders still presents serious drawbacks. Since inherent complexity and lack of satisfactory understanding of the underlying pathophysiology impose limits for rational drug design, resourceful approaches in the search for antipsychotics are pertinent. This paper reports pharmacological properties of alstonine, a heteroyohimbine type alkaloid, Which exbitited an antipsychotic-like profile, inhibiting amphetamine-induced lethaly, apomorphine-induced steotypy and potentiating barbiturate-induced slleping time. Atypical features of alstonine were the prevention of haloperidol-induced catalepsy and lack of direct interaction with D1, D2 and 5-HT2A receptors, classically linked to antipsychotic mechanism of action.
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Índice:
LILACS (Américas)
Asunto principal:
Plantas Medicinales
/
Antipsicóticos
/
Alcaloides de Triptamina Secologanina
Límite:
Animales
País/Región como asunto:
Africa
Idioma:
Inglés
Revista:
An. acad. bras. ciênc
Asunto de la revista:
Ciencia
Año:
1999
Tipo del documento:
Artículo
/
Congreso y conferencia
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