Mechanisms of cell transformation induced by polyomavirus
Braz. j. med. biol. res
; 32(7): 861-5, July 1999.
Article
en En
| LILACS
| ID: lil-234892
Biblioteca responsable:
BR1.1
RESUMO
Polyomavirus is a DNA tumor virus that induces a variety of tumors in mice. Its genome encodes three proteins, namely large T (LT), middle T (MT), and small T (ST) antigens, that have been implicated in cell transformation and tumorigenesis. LT is associated with cell immortalization, whereas MT plays an essential role in cell transformation by binding to and activating several cytoplasmic proteins that participate in growth factor-induced mitogenic signal transduction to the nucleus. The use of different MT mutants has led to the identification of MT-binding proteins as well as analysis of their importance during cell transformation. Studying the molecular mechanisms of cell transformation by MT has contributed to a better understanding of cell cycle regulation and growth control
Texto completo:
1
Índice:
LILACS
Asunto principal:
Transducción de Señal
/
Transformación Celular Neoplásica
/
Antígenos Transformadores de Poliomavirus
/
Poliomavirus
/
Infecciones por Papillomavirus
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1999
Tipo del documento:
Article
/
Congress and conference