Genetic alterations in head and neck squamous cell carcinomas
Braz. j. med. biol. res
;
32(7): 897-904, July 1999.
Artículo
en Inglés
| LILACS
| ID: lil-234897
RESUMO
The genetic alterations observed in head and neck cancer are mainly due to oncogene activation (gain of function mutations) and tumor suppressor gene inactivation (loss of function mutations), leading to deregulation of cell proliferation and death. These genetic alterations include gene amplification and overexpression of oncogenes such as myc, erbB-2, EGFR and cyclinD1 and mutations, deletions and hypermethylation leading to p16 and TP53 tumor suppressor gene inactivation. In addition, loss of heterozygosity in several chromosomal regions is frequently observed, suggesting that other tumor suppressor genes not yet identified could be involved in the tumorigenic process of head and neck cancers. The exact temporal sequence of the genetic alterations during head and neck squamous cell carcinoma (HNSCC) development and progression has not yet been defined and their diagnostic or prognostic significance is controversial. Advances in the understanding of the molecular basis of head and neck cancer should help in the identification of new markers that could be used for the diagnosis, prognosis and treatment of the disease
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Oncogenes
/
Carcinoma de Células Escamosas
/
Genes Supresores de Tumor
/
Neoplasias de Cabeza y Cuello
Límite:
Humanos
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1999
Tipo del documento:
Artículo
/
Congreso y conferencia
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