Genetic susceptibility to HPV infection and cervical cancer
Braz. j. med. biol. res
;
32(7): 915-22, July 1999. tab
Artículo
en Inglés
| LILACS
| ID: lil-234899
ABSTRACT
Squamous cell carcinoma of the cervix (SCCC) is one of the leading causes of death in developing countries. Infection with high-risk human papillomavirus (HPV) is the major risk factor to develop malignant lesions in the cervix. Polymorphisms of the MHC and p53 genes seem to influence the outcome of HPV infection and progression to SCCC, although controversial data have been reported. MHC are highly polymorphic genes that encode molecules involved in antigen presentation, playing a key role in immune regulation, while p53 is a tumor suppressor gene that regulates cell proliferation. The HPV E6 protein from high-risk types binds p53 and mediates its degradation by the ubiquitin pathway. The role of these polymorphisms in genetic susceptibility to HPV infection and to SCCC remains under investigation
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Papillomaviridae
/
Polimorfismo Genético
/
Infecciones Tumorales por Virus
/
Carcinoma de Células Escamosas
/
Neoplasias del Cuello Uterino
/
Genes p53
/
Papillomavirus del Conejo de Rabo Blanco
/
Infecciones por Papillomavirus
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1999
Tipo del documento:
Artículo
/
Congreso y conferencia
País de afiliación:
Brasil
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