Genetic susceptibility to HPV infection and cervical cancer
Braz. j. med. biol. res
; 32(7): 915-22, July 1999. tab
Article
en En
| LILACS
| ID: lil-234899
Biblioteca responsable:
BR1.1
ABSTRACT
Squamous cell carcinoma of the cervix (SCCC) is one of the leading causes of death in developing countries. Infection with high-risk human papillomavirus (HPV) is the major risk factor to develop malignant lesions in the cervix. Polymorphisms of the MHC and p53 genes seem to influence the outcome of HPV infection and progression to SCCC, although controversial data have been reported. MHC are highly polymorphic genes that encode molecules involved in antigen presentation, playing a key role in immune regulation, while p53 is a tumor suppressor gene that regulates cell proliferation. The HPV E6 protein from high-risk types binds p53 and mediates its degradation by the ubiquitin pathway. The role of these polymorphisms in genetic susceptibility to HPV infection and to SCCC remains under investigation
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Índice:
LILACS
Asunto principal:
Papillomaviridae
/
Polimorfismo Genético
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Infecciones Tumorales por Virus
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Carcinoma de Células Escamosas
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Neoplasias del Cuello Uterino
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Genes p53
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Papillomavirus del Conejo de Rabo Blanco
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Infecciones por Papillomavirus
Tipo de estudio:
Etiology_studies
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Risk_factors_studies
Límite:
Female
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Humans
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1999
Tipo del documento:
Article
/
Congress and conference