Marcadores tumorales inmunohistoquímicos en carcinoma ductal infiltrante de la mama / Immunohistochemical tumoral markers in infiltrating ductal mammary carcinoma

ABSTRACT

Background: Immunohistochemical techniques allow the study of tumoral markers with predictive or prognostic value. Aim: To study tumoral markers in mammary carcinoma and to relate these markers with age and tumoral histological grade. Material and methods: The expression of nuclear estrogen receptor (RE), nuclear progesterone receptor (PGR), p53 and c-erb-B2 proteins was analyzed in 382 cases of infiltrating ductal carcinoma of the breast. Results: The histological grade was I in 22 percent tumors, II in 56 percent and III in 23 percent. Forty nine percent of tumors had positive staining for RE, 41 percent for RPG, 45 percent for p53 and 57 percent for c-erb-B2. Correlation was found between histological grade and expression of RE, p53 and c-erb-B2 between RE and PGR, RE and c-erb-B2 and between c-erb-B2 and p53. RE expression correlated with age. Conclusions: A reliable and rapid evaluation of these markers can be achieved using immunohistochemical staining. The present results are similar to other biochemical and immunohistochemical studies