Soluble transferrin receptor in sickle cell diseases: correlation with spleen function
São Paulo med. j
;
117(4): 145-50, July 1999.
Artículo
en Inglés
| LILACS
| ID: lil-247138
ABSTRACT
OBJECTIVE:
To correlate spleen function with soluble transferrin receptor (sTfR) levels and red cell ferritin (RCF) values in patients with sickle cell diseases.DESIGN:
Prospective study. LOCATION University Hospital, School of Medical Sciences, State University of Campinas; a tertiary hospital.PARTICIPANTS:
60 patients with sickle cell diseases, in a steady state, who had not received blood transfusions for 3 months; 28 normal individuals with no clinical or laboratory signs of anemia. MEASUREMENTS Determination of serum iron, transferrin iron-binding capacity, serum ferritin, RCF and sTfR. Evaluation of spleen function erythrocytes with pits were quantified.RESULTS:
Patients with sickle cell anemia had sTfR levels significantly higher than in normal individuals or those with HbSC (p=0.0001) and there was an inverse correlation between sTfR and fetal Hb (p=0.0016). RCF values were significantly higher in sickle cell anemia patients than in normal individuals or those with HbSC (p=0.0001), and there was a correlation between RCF and pitted erythrocytes (p=0.0512).CONCLUSION:
The association between sTfR and fetal Hb confirms the contribution of fetal Hb to improving the hemolytic state by minimizing the consequent reactive erythrocyte expansion. High sTfR levels are not related to the degree of spleen function deficiency seen in sickle cell disease patients. The deficiency in the exocytosis process of the spleen occurring in sickle cell anemia patients may contribute to their accumulation of RCF
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Bazo
/
Receptores de Transferrina
/
Anemia de Células Falciformes
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Humanos
Idioma:
Inglés
Revista:
São Paulo med. j
Asunto de la revista:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicina
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Año:
1999
Tipo del documento:
Artículo
/
Documento de proyecto
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