Vascular changes after cardiopulmonary bypass and ischemic cardiac arrest: roles of nitric oxide synthase and cyclooxygenase
Braz. j. med. biol. res
;
32(11): 1345-52, Nov. 1999.
Artículo
en Inglés
| LILACS
| ID: lil-248428
RESUMO
Cardiac surgery involving ischemic arrest and extracorporeal circulation is often associated with alterations in vascular reactivity and permeability due to changes in the expression and activity of isoforms of nitric oxide synthase and cyclooxygenase. These inflammatory changes may manifest as systemic hypotension, coronary spasm or contraction, myocardial failure, and dysfunction of the lungs, gut, brain and other organs. In addition, endothelial dysfunction may increase the occurrence of late cardiac events such as graft thrombosis and myocardial infarction. These vascular changes may lead to increased mortality and morbidity and markedly lengthen the time of hospitalization and cost of cardiac surgery. Developing a better understanding of the vascular changes operating through nitric oxide synthase and cyclooxygenase may improve the care and help decrease the cost of cardiovascular operations.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Puente Cardiopulmonar
/
Prostaglandina-Endoperóxido Sintasas
/
Isquemia Miocárdica
/
Óxido Nítrico Sintasa
/
Vasos Coronarios
/
Paro Cardíaco Inducido
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1999
Tipo del documento:
Artículo
/
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