Selective destruction of nigrostriatal dopaminergic neurons does not alter [3H]-ryanodine binding in rat striatum
Braz. j. med. biol. res
;
33(2): 237-40, Feb. 2000. tab
Artículo
en Inglés
| LILACS
| ID: lil-252301
RESUMO
Dopamine nigrostriatal neurons are important for motor control and may contain a particularly dense population of ryanodine receptors involved in the control of dopamine release. To test this hypothesis, we used a classical model of unilateral selective lesion of these neurons in rats based on 6-hydroxydopamine (6-OHDA) injection into the substantia nigra. Binding of [3H]-GBR 12935, used as a presynaptic marker since it labels specifically the dopamine uptake complex, was dramatically decreased by 83-100 percent in striatum homogenates after 6-OHDA lesion. On the contrary, no reduction of [3H]-ryanodine binding was observed. The present data indicate that [3H]-ryanodine binding sites present in rat striatum are not preferentially localized in dopaminergic terminals
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Dopamina
/
Oxidopamina
/
Adrenérgicos
/
Canal Liberador de Calcio Receptor de Rianodina
/
Cuerpo Estriado
/
Síndrome Neuroléptico Maligno
/
Neuronas
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
2000
Tipo del documento:
Artículo
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