Heparin and low molecular weight heparin decrease nitric oxide production by human polymorphonuclear cells
Arch. med. res
;
30(2): 116-9, mar.-abr. 1999. graf
Artículo
en Inglés
| LILACS
| ID: lil-256633
ABSTRACT
Background. Heparin and heparin derivatives with low anticoagulant activity exhibit a wide spectrum of biological functions affecting adhesion, activation and trafficking of luekocytes. Methods. We investigated the in vitro effect of heparin and low molecular weight heparin derivative (LMWH) on nitric oxide (NO) production by human polymorphonuclear leukocytes (PMN). Results. N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated NO production was significantly decreased by heparin at doses of 0.5 and 5 µg/mL, while LMWH was only effective at doses of 50 and 200 µg/mL by means of a mechanism not related to No synthase (NOS) activity. Conclusions. These results support the hypothesis that heparin and LMWH derivatives may offet therapeutic benefit for inflammatory diseases where No plays a protagonic role
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Índice:
LILACS (Américas)
Asunto principal:
Heparina
/
Heparina de Bajo-Peso-Molecular
/
N-Formilmetionina Leucil-Fenilalanina
Límite:
Humanos
Idioma:
Inglés
Revista:
Arch. med. res
Asunto de la revista:
Medicina
Año:
1999
Tipo del documento:
Artículo
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