Intoxicación aguda con metotrexato usado con fines abortivos: descripión de 2 casos / Acute intoxication with methotrexate, used as an abortive: report of two cases
Rev. méd. Chile
;
128(3): 315-8, mar. 2000.
Artículo
en Español
| LILACS
| ID: lil-260191
RESUMO
Acute intoxication with methotrexate, used as an abortive, has not been described in Chile. We report two female patients, aged 15 and 24 years old, who presented with mucositis, erythrodermia, pancytopenia, and elevation of hepatic enzymes. Plasma methotrexate levels confirmed the clinical diagnosis and both patients were treated with high leucovorin doses and management of associated complications. In one patient, pregnancy continued, giving birth to a newborn with cranial, face and limb malformations. The second patient had a late rescue with leucovorin and was discharged with a persistent sensory motor neuropathy. Considering the severity of complications and that patients may deny its use, when there is reasonable clinical suspicion of methotrexate intoxication, leucovorin treatment should be started
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Intoxicación
/
Metotrexato
/
Leucovorina
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Embarazo
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2000
Tipo del documento:
Artículo
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