Efeito do carvedilol na insuficiência cardíaca por cardiomiopatia dilatada: resultado de estudo duplo-cego, randômico, com grupo placebo-controle (estudo CARIBE) / Effects of carvedilol in heart failure due to dilated cardiomyopathy: results of a double-blind randomized placebo-controlled study (CARIBE study)
Arq. bras. cardiol
;
74(3): 233-42, mar. 2000. tab, graf
Artículo
en Portugués, Inglés
| LILACS
| ID: lil-265165
RESUMO
OBJECTIVE:
To assess the effects of carvedilol in patients with idiopathic dilated cardiomyopathy.METHODS:
In a double-blind randomized placebo-controlled study, 30 patients (7 women) with functional class II and III heart failure were assessed. Their ages ranged from 28 to 66 years (mean of 43ñ9 years), and their left ventricular ejection fraction varied from 8 per cnet to 35 per cent. Carvedilol was added to the usual therapy of 20 patients; placebo was added to the usual therapy of 10 patients. The initial dose of carvedilol was 12.5 mg, which was increased weekly until it reached 75 mg/day, according to the patient's tolerance. Clinical assessment, electrocardiogram, echocardiogram, and radionuclide ventriculography were performed in the pretreatment phase, being repeated after 2 and 6 months of medication use.RESULTS:
A reduction in heart rate (p=0.016) as well as an increase in left ventricular shortening fraction (p=0.02) and in left ventricular ejection fraction (p=0.017) occurred in the group using carvedilol as compared with that using placebo.CONCLUSION:
Carvedilol added to the usual therapy for heart failure resulted in better heart function.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Volumen Sistólico
/
Carbazoles
/
Gasto Cardíaco Bajo
/
Cardiomiopatía Dilatada
/
Antagonistas Adrenérgicos beta
/
Frecuencia Cardíaca
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio de etiología
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
/
Portugués
Revista:
Arq. bras. cardiol
Asunto de la revista:
Cardiología
Año:
2000
Tipo del documento:
Artículo
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