Angiotensin-(1-7) increases osmotic water permeability in isolated toad skin
Braz. j. med. biol. res
;
33(9): 1099-104, Sept. 2000.
Artículo
en Inglés
| LILACS
| ID: lil-267965
ABSTRACT
Angiotensin-(1-7) (Ang-(1-7)) increased osmotic water permeability in the isolated toad skin, a tissue with functional properties similar to those of the distal mammalian nephron. Concentrations of 0.1 to 10 ÁM were effective, with a peak at 20 min. This effect was similar in magnitude to that of frog skin angiotensin II (Ang II) and oxytocin but lower than that of human Ang II and arginine-vasotocin. The AT2 angiotensin receptor antagonist PD 123319 (1.0 ÁM) fully inhibited the response to 0.1 ÁM Ang-(1-7) but had no effect on the response to Ang II at the same concentration. The specific receptor antagonist of Ang-(1-7), A-779, was ineffective in blocking the response to Ang-(1-7) and to frog skin Ang II. The AT1 receptor subtype antagonist losartan, which blocked the response to frog skin Ang II, was ineffective in blocking the response to Ang-(1-7). The present results support the view of an antidiuretic action of Ang-(1-7) in the mammalian nephron
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Piel
/
Vasoconstrictores
/
Angiotensina I
/
Angiotensina II
/
Agua
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
2000
Tipo del documento:
Artículo
País de afiliación:
Argentina
Institución/País de afiliación:
Fundación INELCO/AR
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