Disfunción endotelial como alteración primaria en las patologías vasculares / Endothelial dysfunction as a primary alteration in vascular diseases
Rev. méd. Chile
;
128(6): 659-70, jun. 2000. ilus, tab
Artículo
en Español
| LILACS
| ID: lil-268152
RESUMO
Endothelium controls vascular smooth muscle tone by secreting relaxing and contracting factors. There is a constant release of endothelium derived relaxing factors, mainly nitric oxide, a potent vasodilator, inhibitor of platelet aggregation, monocyte adhesion and smooth muscle proliferation. In addition, the endothelium may increase the release of NO in response to humoral stimulation by vasoactive substances such as acetylcholine, bradikinin or substance P. Although the endothelium releases a number of products, no single blood test has yet proved useful to determine normal endothelial function or as early abnormalities. The most useful test of endothelial function relies on the meassurement of endothelium-dependent dilatation in response to pharmacological or physiologic stimuli. The alteration of this response is known as endothelial dysfunction and has been observed in a variety of circumstances related to cardiovascular risk. This review summarizes the evidence that sustains this association and emphasizes the clinical utility of assessing endothelial function presenting two clinical cases of hypercholesterolemia in which a high-resolution vascular ultrasound in the braquial artery was used
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Endotelio
/
Aterosclerosis
/
Hipercolesterolemia
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
Límite:
Adulto
/
Child, preschool
/
Femenino
/
Humanos
/
Masculino
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2000
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Chile
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