Short- and long-term memory: differential involvement of neurotransmitter systems and signal transduction cascades
An. acad. bras. ciênc
;
72(3): 353-64, Sept. 2000. graf
Artículo
en Inglés
| LILACS
| ID: lil-269387
RESUMO
Since William James (1890) first distinguished primary from secondary memory, equivalent to short- and long-term memory, respectively, it has been assumed that short-term memory processes are in charge of cognition while long-term memory is being consolidated. From those days a major question has been whether short-term memory is merely a initial phase of long-term memory, or a separate phenomena. Recent experiments have shown that many treatments with specific molecular actions given into the hippocampus and related brain areas after one-trial avoidance learning can effectively cancel short-term memory without affecting long-term memory formation. This shows that short-term memory and long-term memory involve separate mechanisms and are independently processed. Other treatments, however, influence both memory types similarly, suggesting links between both at the receptor and at the post-receptor level, which should not be surprising as they both deal with nearly the same sensorimotor representations. This review examines recent advances in short- and long-term memory mechanisms based on the effect of intra-hippocampal infusion of drugs acting upon neurotransmitter and signal transduction systems on both memory types.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Transducción de Señal
/
Sistema Nervioso Central
/
Neurotransmisores
/
Memoria
Límite:
Animales
Idioma:
Inglés
Revista:
An. acad. bras. ciênc
Asunto de la revista:
Ciencia
Año:
2000
Tipo del documento:
Artículo
País de afiliación:
Argentina
/
Brasil
Institución/País de afiliación:
Universidad de Buenos Aires/AR
/
Universidade Federal do Rio Grande do Sul/BR
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