Increased fetal hemoglobin levels in patients infected with human immunodeficiency virus (HIV1/2)
Braz. j. med. biol. res
;
33(11): 1313-5, Nov. 2000. tab
Artículo
en Inglés
| LILACS
| ID: lil-273208
ABSTRACT
Fetal hemoglobin was measured in HIV1/2 patients under treatment with combined therapy (zidovudine and a protease inhibitor). A total of 143 patients and 103 normal individuals were investigated by the quantitative method of Betke and the semi-quantitative acid elution method of Kleihauer. In the normal person, hemoglobin F makes up less than 1 percent and an increase higher than 1.5 percent was observed in 21.4 percent of HIV patients by the method of Betke and in 24.8 percent of HIV-infected patients by the method of Kleihauer. The quantitative biochemical method of Betke showed that the populations were significantly different (two-tailed Mann-Whitney test). The reason for this hemoglobin F increase might be ascribed to the effect of zidovudine or to direct viral action on gamma chain expression. The finding of a higher F cell frequency indicated by the method of Kleihauer rather suggests that there is an increased F cell clone proliferation rather than an increase in hemoglobin F level in every cell
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Hemoglobina Fetal
/
Infecciones por VIH
Tipo de estudio:
Estudio observacional
Límite:
Humanos
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
2000
Tipo del documento:
Artículo
/
Congreso y conferencia
País de afiliación:
Brasil
Institución/País de afiliación:
Instituto Adolfo Lutz/BR
/
Universidade Federal do Rio Grande do Norte/BR
/
Universidade de Säo Paulo/BR
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