Double-blind clonazepam vs placebo in panic disorder treatment
Arq. neuropsiquiatr
; 58(4): 1025-9, Dec. 2000.
Article
en En
| LILACS
| ID: lil-273842
Biblioteca responsable:
BR1.1
ABSTRACT
OBJECTIVE:
To assess the effectiveness of clonazepam, in a fixed dose (2 mg/day), compared with placebo in the treatment of panic disorder patients.METHOD:
24 panic disorder patients with agoraphobia were randomly selected. The diagnosis was obtained using the structured clinical interview for DSM-IV . All twenty-four subjects were randomly assigned to either treatment with clonazepam (2 mg/day) or placebo, during 6 weeks. Efficacy assessments included change from baseline in the number of panic attacks; CGI scores for panic disorder; Hamilton rating scale for anxiety; and panic associated symptoms scale.RESULTS:
At the therapeutic endpoint, only one of 9 placebo patients (11.1 percent) were free of panic attacks, compared with 8 of 13 (61.5 percent) clonazepam patients (Fisher exact test; p=0,031).CONCLUSION:
the results provide evidence for the efficacy of clonazepam in panic disorder patients
Texto completo:
1
Índice:
LILACS
Asunto principal:
Trastorno de Pánico
/
Clonazepam
/
Moduladores del GABA
/
Agorafobia
Tipo de estudio:
Clinical_trials
/
Qualitative_research
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Arq. neuropsiquiatr
Asunto de la revista:
NEUROLOGIA
/
PSIQUIATRIA
Año:
2000
Tipo del documento:
Article