Monitorizaçäo ambulatorial da pressäo arterial e microalbuminúria em diabéticos insulino-dependentes normotensos / Ambulatory blood pressure monitoring and microalbuminuria in normotensive subjects with insulin-dependent diabetes mellitus
Arq. bras. cardiol
;
75(3): 195-204, set. 2000. tab
Artículo
en Portugués, Inglés
| LILACS
| ID: lil-274140
RESUMO
OBJECTIVE:
To assess the association between microalbuminuria with ambulatory blood pressure monitoring in normotensive individuals with insulin-dependent diabetes mellitus.METHODS:
Thirty-seven patients underwent determination of the rate of urinary excretion of albumin through radioimmunoassay and ambulatory blood pressure monitoring. Their mean age was 26.5 + or - 6.7 years, and the mean duration of their disease was 8 (1-34) years. Microalbuminuria was defined as urinary excretion of albumin > or = 20 and <200µg/min in at least 2 out of 3 urine samples.RESULTS:
Nine (24.3 per cent) patients were microalbuminuric. Ambulatory blood pressure monitoring in the microalbuminuric patients had higher mean pressure values, mainly the systolic pressure, during sleep as compared with that in the normoalbuminuric patients (120.1 + or - 8.3 vs 110.8 + or - 7.1 mmHg; p=0.007). The pressure load was higher in the microalbuminuric individuals, mainly the systolic pressure load during wakefulness [6.3 (2.9-45.9) vs 1.6 (0-16 per cent); p=0.001]. This was the variable that better correlated with the urinary excretion of albumin (rS=0.61; p<0.001). Systolic pressure load >50 per cent and diastolic pressure load > 30 per cent during sleep was associated with microalbuminuria (p=0.008). The pressure drop during sleep did not differ between the groups.CONCLUSION:
Microalbuminuric normotensive insulin-dependent diabetic patients show greater mean pressure value and pressure load during ambulatory blood pressure monitoring, and these variables correlate with urinary excretion of albumin.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Presión Sanguínea
/
Monitoreo Ambulatorio de la Presión Arterial
/
Diabetes Mellitus Tipo 1
/
Albuminuria
Tipo de estudio:
Estudio diagnóstico
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
/
Portugués
Revista:
Arq. bras. cardiol
Asunto de la revista:
Cardiología
Año:
2000
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade do Estado do Rio de Janeiro/BR
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