Stability studies of tolbutamide/ß-cyclodextrin inclusion complexes
RBCF, Rev. bras. ciênc. farm. (Impr.)
;
36(1): 111-20, jan.-jun. 2000. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-276140
RESUMO
The ability of cyclodextrins to encapsulate many molcecules is used to improve the properties of drugs. Complexes of tolbutamide with ß-cyclodextrin were prepared by coprecipitation, kneading and freeze-drying. The inclusion complexes were stored under controlled conditions at 5ºC, 40ºC, 50ºC and 40ºC/75 per cent relative humidity. The influence of temperature and the humidity was examined by performing DSC thermal analysis, X-ray diffractometry, Raman spectroscopy and dissolution rate measurements. The results indicated that the interactions and dissolution rate of TBM/ß-CD inclusion complexes obtained by coprecipitation and kneading were unchanged after storage at 5ºC, 40ºC, 50ºC and 40ºC/75 per cent RH over six months...
Buscar en Google
Índice:
LILACS (Américas)
Asunto principal:
Tolbutamida
/
Ciclodextrinas
/
Estabilidad de Medicamentos
Idioma:
Inglés
Revista:
RBCF, Rev. bras. ciênc. farm. (Impr.)
Asunto de la revista:
Bioquímica
/
Farmacia
/
Farmacología
Año:
2000
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS