An evaluation by rat colon anastomosis of the efficacy of fibrin glue derived from snake venom
J. venom. anim. toxins
;
6(2): 180-93, 2000. ilus, graf
Artículo
en Inglés
| LILACS
| ID: lil-276607
RESUMO
The objective of this study was to evaluate the efficacy of fibrin adhesive made up of snake venom and bubaline fibrinogen by rat colon anastomosis. Eighty rats were randomly assigned into 2 experimental groups GI control (anastomosis with extramucous interrupted suture) and GII (repair suture + fibrin glue). The animals were studied at the following 4 times T0 - preoperative - T1 - 7th day postoperative, T2 - 14th day postoperative, and T3 - 21th day postoperative. The macroscopic characteristics of the intestinal segment open and closed anastomosis and the bursting strength of the anastomosed segments were observed at each of the above times. The results showed that the anastomosed segments coapted and there was no difference in the bursting strength values between the 2 groups. There was a decrease in the bursting strength values up until de 7th day postoperative in both groups with its progressive increase at the other times. Although important experimental studies using large animals are needed for a better evaluation of tissue repair processes, this adhesive may become a valuable tool for use in anastomosis.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Cicatrización de Heridas
/
Adhesivo de Tejido de Fibrina
/
Colon
Tipo de estudio:
Estudio observacional
Límite:
Animales
Idioma:
Inglés
Revista:
J. venom. anim. toxins
Asunto de la revista:
Toxicología
Año:
2000
Tipo del documento:
Artículo
País de afiliación:
Brasil
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